Antibodies
Mono- / polyclonal antibodies
The antibodies can be applied for different disease research areas.
NEUROSCIENCE ANTIBODIES
Neurogenerative diseases, caused by neuron loss in the nervous system, lead to disorders like dementia, memory loss, and ataxia. Addressing these challenges requires precise tools for research and diagnostics.
WellMarin offers high-quality antibodies and recombinant proteins, enabling detailed studies of neuronal function, protein expression, and cellular interactions.
CNS targets: GFAP, Iba1, TREM2
Applications
Advantages
Neuscience antibodies for research use. Minimum delivery quantity: 500µg.
Bulk ammounts and pharmacetical quality upon request.
TUMOR ASSOCIATED CARBOHYDRATE ANTIGENS
TACAs are key targets in cancer research due to their abnormal expression on cancer cells, driving tumor progression and immune evasion. These include
• truncated O-glycans (Tn, STn, T),
• gangliosides (GD2, GD3),
• polysialic acids,
• Lewis antigens (sLea, sLex),
• mucine antigen MUC1
Their unique patterns make them valuable for early cancer detection and immunotherapy.
Figure: Structures of common tumor-associated charbohydrate antigens (TACAs)
• Truncated O-glycans, such as Tn and STn, help distinguish malignant cells from normal tissue, supporting precision diagnostics.
• Lewis antigens like sLea/CA19-9, are critical markers for gastrointestinal cancers.
• Gangliosides (GD2, GD3) and polysialic acid are key targets in neorogenic and CNS tumors.
• Mucin antigen MUC1, with aberrant glycosylation, places a significant role in breast, ovarian, and colorectal cancers, offering opportunities for innovative therapies to suppress tumor grows and recurrence.
ANTIBODIES POWERING CANCER IMMUNE THERAPY DEVELOPMENT
• PD-1, CTLA-4, LAG-3 targets
• For checkpoint therapy & ADCC assays
• In vivo-ready, low endotoxin certified
Validation Data: FACS
ANTIBODIES POWERING THERAPY DEVELOPMENT AGAINST AUTOIMMUNE AND INFLAMMATORY DISEASES
• RA/SLE/IBD validated
• Key cytokines & autoantibodies detection
• Th17/Treg & immune balance
Validation Data: Binding Affinity
ALLERGY RELATED ANTIBODIES
Allergic diseases affect over a quarter of the population in industrialized countries, posing a significant public health challenge. Triggered by hypersensitivity of the immune system, allergies lead to IgE antibody production, causing inflammation and dysfunction. Common allergens include dust mites, pollen, pet dander, and certain foods.
WellMarin provides cutting-edge allergy testing solutions, including anti-IgE antibodies. Our key IgE antibodies enable precise detection and research of IgE-mediated allergic reactions, supporting effective allergy management and advancing scientific innovation.
Figure: IgE and ist receptors
ANTI-DNA / RNA ANTIBODIES
DNA and RNA, as carriers of genetic information, play intricate roles in physiological regulation, influenced by their diverse structures and nucleoside sequences. Ongoing research has emphasized their importance beyond mere information storage, highlighting their critical functions in biological processes.
WellMarin offers a broad range of recombinant antibodies designed to recognize specific nucleotide configurations, including
§ single-stranded DNA (ssDNA),
§ double-stranded DNA (dsDNA),
§ hairpin DNA structures,
§ Z-DNA,
§ DNA/RNA hybrids,
§ i-Motif,
§ G-quadruplexes,
§ various RNA subtypes such as U1-U6, mRNA, hnRNA, and snRNA.
These antibodies are carefully engineered through advanced protein design techniques to specifically bind to primary, secondary, and tertiary nucleotide structures, enabling precise and cutting-edge genetic research.
BIOSIMILARS
Biosimilars are biologic products that are highly similar to already approved reference biologics. Unlike generics, which are chemically identical, biosimilars may have minor differences due to complex production processes. However, these differences do not affect safety, efficacy, or quality. Biosimilars provide a reliable and affordable alternative for preclinical and mechanistic studies.
Why choose WellMarin biosimulars?
ü High similarity to originator molecules
ü Verified binding activity (e.g. ELISA, SDS-PAGE)
ü Competitive pricing and consistent lot availability
Figure: Comparative structure of Inflixymab, Adalimumab, and Etanercept building to TNFα
Validation Data: Antigen Binding
BISPECIFIC ANTIBODIES
To support proof-of-concept (POC) studies, WellMarin offers a comprehensive range of murine bispecific antibodies for in vivo experiments. Additionally, we offer custom design and development services for bispecific antibodies targeting randomly selected antigens.
ü Fully murine structure design minimizes immune response in mouse models.
ü IgG-like structure ensures optimal performance of the antibody in research applications.
ü Low endotoxin and high purity levels: Ideal for in vivo cancer research.
ü Proven efficacy: Demonstrated effectiveness in T-cell-mediated tumor cell eradication in murine systems.
NANOBODIES
A nanobody (nb) is an innovative antibody derived from llamas, consisting of a single heavy chain variable domain (VHH). With a molecular weight of only 15 kda, it is the smallest known antigen-binding unit. Its exceptional solubility, stability, and highest specificity make it a powerful tool for precise targeting and diverse experimental applications.
Figure: Procedure of Nanpbody development
Applications
ANTIBODIES FOR IN VIVO MODELS
§ WellMarin offers an extensive library of over 400 high-quality In Vivo antibodies, meticulously designed and validated for in vivo research.
§ Our antibodies ensure superior purity, specificity, and functionality, making them ideal for studying disease mechanisms, immune analysis, and drug development.
§ Available in milligram to gram quantities, all products are in stock and ready for rapid delivery to meet diverse research needs.
ü Ready for in vivo use
ü Low endotoxin levels
ü Suitable for immune modulation
ANTIBODIES FOR FLOW CYTOMETRY
High-performance antibodies for immune cell profiling and functional assays
üCheckpoint & Functional Markers
ü Multicolor panel compatibility
ü LowBackground, HighSpecificity
Validation Data: FACS
TAG & LOADING CONTROL ANTIBODIES
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Nulla euismod condimentum felis vitae efficitur. Sed vel dictum quam, at blandit leo.
Recombinant Proteins
ANTIGENS FOR IMMUNE THERAPY
Interactions within the Tumor Microenvironment
Drug targets, essential for therapeutic inventions, are primarily proteins implicated in disease mechanisms. Utilizing recombinant proteins in drug discovery enables precise evaluation of drug-target interactions, which is crucial for screening and optimization processes. WellMarin offers high-quality validated recombinant proteins that provide valuable qualitative and quantitative insights for advancing disease research.
ALLERGY RELATED RECOMBINANT PROTEINS
Allergic diseases affect over a quarter of the population in industrialized countries, posing a significant public health challenge. Triggered by hypersensitivity of the immune system, allergies lead to IgE antibody production, causing inflammation and dysfunction. Common allergens include dust mites, pollen, pet dander, and certain foods.
WellMarin provides cutting-edge allergy testing solutions, including recombinant allergen proteins. Our key products, such as Der f 1, Fel d 1, and Ara h 2, enable precise detection and research of IgE-mediated allergic reactions, supporting effective allergy management and advancing scientific innovation.
Figure: IgE receptors